Thiazoles and their derivatives are an important class of five-member heterocyclic compounds, and contain sulfur and nitrogen at positions 1 and 3 of the thiazole ring, respectively. The thiazole scaffold is found in a variety of natural bioactive compounds used as pharmaceuticals and agrochemicals. Thiazole analogues have continued to attract interest in medicinal chemistry field during the past decades due to their wide ranging biological activities, which include antibacterial (Alam et al. 2013), antioxidant (Shih and Ying 2004), antitubercular (Romagnoli et al. 2014), antipsychotropic (Zablotskaya et al. 2013), antiarthritic (Nishikaku and Koga 1993), neuroprotective (Zhang et al. Moreover, the 1,3-thiazole scaffold is commonly utilized in drug development, and found in many commercially available drugs, including tenonitrozole (an antiparasitic) (Cohen et al. 2012), penicillin derivatives (antibacterial) (Ye et al. 2014), bleomycin (anticancer) (Rahmutulla et al. 2014), tiazofurin (antineoplastic) (Popsavin et al.
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